Produced by rapper R.A. the Rugged Man, it stars Charlee Danielson and Anthony Sneed as sexually unfulfilled people who are drawn together because of their mutated genitalia.

Jennifer gets aroused by this, and returns the next night, only to discover that Batz's penis has left his body, and is having sex with numerous women throughout the city.

The film has cameos by J-Zone, Wu-Tang Clan affiliate Remedy, Penthouse Pet Krista Ayne, Reef the Lost Cauze, Vinnie Paz, Staff Sergeant John A. Thorburn, film director James Glickenhaus, and Playboy model Jelena Jensen.

In order to make sure she was committed, Henenlotter tried to scare her off, but he was glad when she stayed with the project, as he said that she was "absolutely perfect" for the part.

[9] Bloody Disgusting rated it 4.5/5 stars and wrote, "Bad Biology is simply the most entertaining gore film I've seen in a very long time.

"[10] Andy Mauro of Dread Central rated it 3.5/5 stars and wrote, "Small complaints aside, fans of Frank Henenlotter should definitely seek Bad Biology out.

"[11] Justin Decloux of Twitch Film wrote, "Keep your expectations in check, because while Bad Biology is a fun gross out chuckle fest, it's by no means the mondo madness that word of mouth has made it out to be.

"[3] Ian Jane of DVD Talk rated it 3.5/5 stars and wrote, "It's not the best starting place for those new to his filmography and he's definitely made better pictures, but the rampant spirit of lunacy and comedic perversion that earned him his following has not dulled.