[1] It stars Kevin Van Hentenryck reprising his role as Duane Bradley, who moves with his deformed, formerly conjoined twin brother Belial into a home for "unique individuals" run by their deceased aunt’s friend, eccentric philanthropist Granny Ruth (played by Annie Ross).

She has been pregnant for six years as her baby refuses to leave her womb; upon revealing this, a grotesque lamprey-like creature emerges from Susan's surgical wounds where failed cesarean sections have been attempted.

[5] Kevin Thomas of the Los Angeles Times complimented the film's atmosphere, which he felt was aided by the cinematography and score, and highlighted Ross and Van Hentenryck's performances.

[6] He wrote that Basket Case 2 "has everything it needs to become the cult film that its 1982 predecessor has been: outrageous dark humor, bizarre horror, driving energy and genuine pathos.

"[6] Joe Kane of the New York Daily News gave the film a mostly positive review, commending its "dark wit" and exploration of Duane and Belial's romantic pursuits.

"[7] In his 2011 book Horror Films of the 1990s, John Kenneth Muir opined that Basket Case 2 was "disappointing" and that it "eschews all the qualities that made the down-and-dirty, low-budget original such a great pleasure.