Loosely inspired by Mary Shelley's 1818 novel Frankenstein; or, The Modern Prometheus, the film stars James Lorinz as medical school dropout Jeffrey Franken and former Penthouse Pet Patty Mullen as the title character.

Jeffrey Franken, a young man who lives in Ho-Ho-Kus, New Jersey, is a power plant worker and an amatueur scientist who specializes in bioelectricity.

His grief drives him to have mock dinner dates with the few pieces of Elizabeth he could salvage, as well as performing self-trepanations with a power drill to help himself calm down.

Deciding he is doing nothing wrong as crack will probably kill the prostitutes anyway, Jeffrey lures them all into a hotel room under the guise of a "medical examination" and marks the women with the body parts he wants for Elizabeth.

However, as he begins to have second thoughts, the prostitutes all find the bag of super-crack and all smoke it despite Jeffrey's pleas, causing them all to explode into pieces.

Jeffrey hurriedly puts the body parts into trash bags, promising to restore the women once he brings Elizabeth back.

However, the spare prostitute parts have also been reanimated by the storm and merged into multiple grotesque limbed monsters, which overwhelm Zorro and drag him away into their storage cooler to his presumed death, along with his drugs.

[4] Frankenhooker was released on VHS in 1990, by Shapiro-Glickenhaus Entertainment, and had an interactive box which had the titular character exclaim "wanna date?!"

[7] Variety wrote, "Frankenhooker is a grisly, grotesque horror comedy recommended only for the stout of heart and strong of stomach.

"[8] Vincent Canby of The New York Times wrote that "there is a legitimate sense of the absurd lurking within Frank Henenlotter's Frankenhooker", but it is "overshadowed by special effects" and elements that recall softcore pornography.