[11] Sellers represented South Carolina's 90th district in the lower house of the state legislature from 2006 to 2014, becoming the youngest African American person elected official in the country at age 22.

[citation needed] He vacated his seat in the South Carolina House of Representatives to run for Lieutenant Governor in 2014, but lost to Henry McMaster.

He first attended the annual American Israel Public Affairs Committee (AIPAC) conference while serving as a student body president at Morehouse College.

[14] In response to an incident between a teenager, Nicholas Sandmann, and Native American activist Nathan Phillips at the Lincoln Memorial, Sellers tweeted about the teen: "He is a deplorable.

[24] In May 2020, Sellers released an autobiography, My Vanishing Country, that centers on the forgotten lives of African-American working-class people in the rural U.S.