The Baltimore Pike is a two-lane undivided road and runs north-northeast past a few businesses, crossing into East Nottingham Township.

The road curves northeast and passes through a mix of farmland and woodland with some residential and commercial development, running a short distance to the northwest of an East Penn Railroad line.

[2][3] Baltimore Pike turns to the north-northeast at the Barnsley Road intersection and passes through commercial areas with some residences before crossing into the borough of Oxford.

[2][3] Baltimore Pike continues through a mix of farmland and woodland with some homes and businesses, crossing the West Branch Big Elk Creek and passing to the north of the Lincoln University campus.

The road heads back into London Grove Township and becomes East Baltimore Pike, continuing through a mix of farms, woods, and development.

The one-way pair continues through business areas with some farm fields and residential developments, crossing the West Branch Red Clay Creek and entering Kennett Township.

Upon crossing into the borough of Kennett Square, the one-way pair becomes borough-maintained and the name of the westbound direction becomes West State Street.

The road heads into wooded areas with some homes and businesses, at which point PA 52 splits in the community of Hamorton to continue southeast toward the city of Wilmington, Delaware.

In Concordville, US 322 splits to the southeast and US 1 continues along Baltimore Pike, intersecting Concord Road before heading into more wooded areas with occasional businesses and crossing the West Branch Chester Creek.

[2][4] Baltimore Pike curves to the east and enters the borough of Chester Heights, running past businesses before heading into forested areas, where it passes north of the corporate headquarters of Wawa.

Following this, Baltimore Pike continues east and passes between the Promenade at Granite Run residential and retail center to the north and Riddle Memorial Hospital to the south, coming to an interchange with PA 352.

[2][4] Past this interchange, Baltimore Pike continues east as SR 2016, passing through woodland and crossing the Ridley Creek into Upper Providence Township.

Baltimore Pike comes to an intersection with PA 320 and continues past more businesses, fully entering Springfield Township again and becoming a five-lane road with a center left-turn lane.

The road curves to the east-northeast and crosses PA 420, becoming the border between Springfield Township to the north and the borough of Morton to the south past this intersection.

The median turns into a center left-turn lane as the road passes more commercial establishments, becoming the border between the borough of Clifton Heights to the north and Upper Darby Township to the south.

Baltimore Avenue fully enters Clifton Heights and passes through residential and commercial areas as a two-lane undivided road.

After passing through the commercial downtown, the road crosses SEPTA's Media–Sharon Hill Line at the Baltimore Pike station and runs past more businesses.

Baltimore Avenue crosses the Darby Creek into the borough of Lansdowne and heads into wooded areas of homes, curving to the east.

Baltimore Avenue crosses the abandoned Newtown Square Branch railroad right-of-way and becomes the border between the borough of East Lansdowne to the north and Upper Darby Township to the south, lined with more businesses.

Immediately after crossing the creek, the road comes to the Angora Loop at 61st Street, which serves as the terminus of SEPTA's Route 34 trolley line.