[2][3][4] Casadei was awarded an academic scholarship to study medicine at the Collegio Nuovo of the University of Pavia, Italy.
[5] She graduated cum Laude in 1984 and then went on to a tenure-track training post in the University Department of Medicine in Varese, Italy.
She is a fellow of the Royal College of Physicians since 2001 and a professor in Cardiovascular Medicine at the University of Oxford since 2006.
She was awarded a BHF Chair in Cardiovascular Medicine in 2012 and elected to the Fellowship of the UK Academy of Medical Sciences (FMedSci) in 2013.
She provides a clinical service at the Oxford University Hospitals NHS Trust's John Radcliffe Hospital and leads a bench-to-bedside translational research programme focussed on atrial fibrillation, which spans from clinical trials to bench-based investigation in human tissue and cells.