The Piazza Barberi includes the Church of San Bartolomeo [it] which houses a fragment of an annunciation by the school of Giotto (14th-15th century) and a bust in bronze by Pietro Tacca.

[1] The Via Francesco da Barberino, named for Francesco da Barberino, leads to the 14th century Porta Senese (Sienese Gate), and the Ospedale dei Pellegrini (Pilgrims' Hospice) dating from 1365.

The Church of Sant'Appiano was built during the 11th century (part in stone) and 12th century (part in brick) and now includes the Antiquarium Museum housing various Etruscan artefacts from the many necropoli in the area, the village of Linari, the Castle of Poppiano at Vico d'Elsa and Petrognano.

The Chapel of San Michele Arcangelo was built in 1597 by Santi di Tito as a perfect 1:8 scale reproduction of the Cupola of the Cathedral of Florence.

The noble Barberini family dynasty began at Barberino Val d'Elsa in the 11th century.