The film centers around Thumbelina, a "twillerbee" who befriends a human girl, and both must cooperate their strength in order to save the environment.

Meet a tiny girl named Thumbelina who lives in harmony with nature in the magical world of the Twillerbees that's hidden among the wildflowers.

At the whim of a spoiled young girl named Makena, Thumbelina and her two friends have their patch of wildflowers uprooted and are transported to a lavish apartment in the city.

Harnessing the magic of nature, Thumbelina sets out to prove that even the smallest person can make a big difference.

The plants, now potted, are placed in an apartment belonging to the parents of a spoiled, wealthy girl named Makena; she keeps the flowers in her bedroom.

Makena talks to her friend Violet on a cell phone about her parents, who intend to build a factory on the Twillerbees' field.

Makena, determined to show off in front of her friends, agrees to the deal but only perfunctorily talks to her parents about the factory project.

That night, Makena, Thumbelina, Janessa, Chrysella, Poofles, and Lola the bird all work hard in a greenhouse to grow the plants.