It is one of the most important railway stations in Italy, with an annual ridership of 14 million.

In the first half of the 20th century it was further enlarged and renewed and in 1946, after World War II, the most recent renovation project was started.

It is a large junction station with 16 platforms for passenger service (13 for FS trains, 3 for FSE).

On the west side of Piazza Aldo Moro are the entrances to the Ferrotramviaria and Ferrovie Appulo Lucane stations, with 3 and 2 platforms respectively.

For long-distance transport it is served by Le Frecce (Frecciargento and Frecciabianca), InterCity and Express trains to Rome, Milan, Bologna, Turin and Venice.