[2][3] From his father, Bartholomew inherited the lordship of Tinos, Mykonos, and parts of Kea and Serifos in the Duchy of Naxos, and from his mother one of the triarchies of Euboea (according to Raymond-Joseph Loenertz the central triarchy of Chalkis[4]), while his father's other possession by his first wife, the Barony of Chalandritsa in the Principality of Achaea, returned to a member of the Dramelay family, Nicholas of Dramelay.
[5] At some unspecified date, Batholomew married a daughter of the Grand Constable of Achaea, Engilbert of Liederkerque,[3][6] and had a son, George II Ghisi.
The Catalans were expelled from the city following the intervention of Venice, but the situation on the island remained complicated following the death of Boniface of Verona, lord of Karystos.
[3] Venetian mediation led to the signing of a truce of all involved parties on 19 June 1319; Bartholomew signed it along with the Venetian bailo of Negroponte, Francesco Dandolo, John de Noyer de Maisey, triarch of the southern third of Euboea, Pietro dalle Carceri and Andrea Corner, lords of the two northern sixths of the island, and Alfonso Fadrique for the Catalans.
As a vassal of the Prince of Achaea, Bartholomew Ghisi participated in the army sent against the Byzantines, but in a battle on 9 September at the castle of Saint George, he was taken prisoner, along with several high-ranking nobles of the Principality, and was sent to Constantinople.
[14] In 1331/32, Bartholomew reverted to an hostile attitude toward the Catalans (perhaps partly because of the dismissal of Alfonso Fadrique from the post of vicar-general) and backed Walter VI of Brienne in his abortive attempt to enforce his ancestral claims on the Duchy of Athens.