George II Ghisi (Italian: Giorgio Ghisi; died c. 1344/5 or 1352) was a Latin feudal lord in medieval Greece, lord of Tinos and Mykonos and Triarch of Negroponte.
As Simona's dowry, the Ghisi received half the castellany of the Castle of Saint Omer in Thebes, which they held until its destruction in c. 1331/34.
In 1343, at the request of Pope Clement VI, he armed a galley conjointly with John I Sanudo (duke of Naxos) and Balzana Gozzadini (regent of the two other thirds of Negroponte) to join the first Smyrniote crusade.
According to Raymond-Joseph Loenertz, his disappearance from the sources after the events of 1344/45 could suggest that he may have participated in person and died in the fighting, as did the leaders Henry of Asti, Martino Zaccaria and the Venetian admiral Pietro Zeno.
[2] He was followed by his son, Bartholomew III Ghisi, who was still a minor, under the regency of his mother Simona until 1358.