Around 1650 Biscaino entered the workshop of Valerio Castello, and from roughly that year his first known work, which still finds him a clumsy and immature artist, was the canvas representing St Ferrando in the act of imploring the Virgin.
Almost at the same time Biscaino worked on the canvases representing the Alms of St Louis King of France and Death of Cleopatra, both preserved in the Palazzo Bianco gallery in Genoa.
In these canvases, the colors were not very vibrant, but the painter achieved a greater compositional balance, even if he did not get to possess a personal style, since he did not yet show the later influence of Rubens and Pellegro Piola.
On the other hand, the existing canvas in the Pinacoteca Civica of Savona, representing Triumph of David and in Moses Saved from the Waters,[1] he has more maturity.
The last works of Bisciano, before his young death from plague, were the three paintings preserved in the Dresden Gallery and depicting Christ and the Adulteress, Presentation at the Temple and Adoration of the Magi.