[3] D'Souza was appointed Bishop of Mangalore Diocese on 22 March 1965, and consecrated on 11 May 1965 by Abp James Robert Knox, papal nuncio in India.
[1] He organised the welcoming arrangements for Pope John Paul II during his historic visit to Mangalore on 6 February 1986.
[1] D'Souza's long tenure saw the establishment of several new parishes (mainly in the remote villages) and institutions such as family guidance centres.
[2] He founded a new mission outside the Mangalore Diocese at Bidar in northern Karnataka, where the number of Christians was small.
[3] During his time of death, D'Souza was just five years away from retirement [3] His remains were interred at the Rosario Cathedral on 9 September 1996.