The Basilica dell'Osservanza is a church on the outskirts of Siena, region of Tuscany, Italy.
A hermitage is known at the site since 1192, and in 104 was donated to San Bernardino of Siena, who began construction of a church around 1420, consecrated in 1451 by the Archbishop Niccolo Piccolomini, and completed around 1490, probably designed by Francesco di Giorgio (Cecco di Giorgio).
Four canvases were painted by Franellini, and the pilasters had terra cotta reliefs by Della Robbia depicting an Annunciation.
The walls had paintings by Margaritone d'Arezzo, Stefano di Giovanni, Alessandro Casolani, and Ramacciotti.
An elaborate urn (1472) by Francesco d'Antonio contained the vestments of San Bernardino.