The church is largely a reconstruction from 1498-1504; the architectural design is attributed to Francesco di Giorgio, and Pandolfo Petrucci.
The interior houses the funeral monument of a number of Spaniards, including Daniel Burgos, Ferdinando Alvarez, Pietro Crispo Spagnuoli, and a chapel (Cappella degli Spagnoli) which is one of Sodoma's masterpieces.
Other works in the church include a Jesus at Gesthemane, a Deposition, and a St Vincent by Giovanni Paolo Pisani.
The church once held the relics of Santa Orsina, once in the suppressed Monastery of Vita Eterna.
[1] The church also has a terracotta nativity scene or presepe by Ambrogio della Robbia.