The fort fell to the Ottomans in 1463 during their conquest of Kingdom of Bosnia, but was soon retaken by Hungarian king Matija Korvin's counter offensive on 26 December of the same year.

Berislavić's forces consisted of 4,000 cavalry, 6,000 infantry (mostly from Croatia), and some Hungarian artillery, but they failed to capture any of the surrounding forts held by the Ottomans.

[3] By October 1518 the town defenders again ran out of food, but managed to temporarily provide themselves by attacking and plundering unsuspecting Ottoman party which passed close to Jajce with supplies from Bočac.

[5] Berislavić was killed in Ottoman ambush in May 1520 at Battle of Plješivica, but Croatian forces under new commanders continued to break through to besieged Jajce, such as under Krsto (Christoph) Frankapan who again successfully reprovisioned the town in June 1525.

Under command of ban Petar Keglević (1521–1525) and captain Mihailo Turek, Jajce successfully repelled three more Ottoman assaults (in 1521, 1524, and 1525), but finally surrendered in 1527, after the battle of Mohacs.