In December 1499, the Venetians attacked Lepanto with the hope of regaining the territories which they lost with the Battle of Zonchio.

He stayed in Lepanto between April and May 1500, where his ships were repaired by an army of 15,000 Ottoman craftsmen who were brought from the area.

From there he sailed towards the Island of Sapientza (Sapienza) and sank the Venetian galley "Lezza".

In September 1500, Kemal Reis assaulted Voiussa and in October he appeared at Cape Santa Maria on the Island of Lefkada before ending the campaign and returning to Constantinople in November.

With the Battle of Modon, the Ottoman fleet and army quickly overwhelmed most of the Venetian possessions in Greece.