Meskhetian lords had recognized that under Qvarqvare's rule Samtskhe would finally turn to the Enemy's hands.

They made an alliance with the Georgian kings, Bagrat III of Imereti and Luarsab I of Kartli to end up Jaqelian rule and protect Samtskhe from dominant Muslim empires (Ottomans and Safavids).

[2] In 1535 King Bagrat III with help of prince Rostom Gurieli and Mingrelian allies invaded Samtskhe.

Qvarqvare died in prison, while Rostom of Guria was awarded Adjara and Lazeti.

[3] A few years later, Qvarqvare's survived youngest son Kaikhosro II requested Ottomans to expel Imeretian and Kartlian forces from Samtskhe.