His failure to capture the throne at the death of his father Kaikhosro may have been caused by the ambition of his uncle Mzetchabuki, who had seized Atabeg's title from him.

Meskhetian lords had recognized that under Qvarqvare's rule Samtskhe would finally turn to the Enemy's hands.

They made an alliance with the Georgian kings, Bagrat III of Imereti and Luarsab I of Kartli to end up Jaqelian rule and protect Samtskhe from dominant Muslim empires (Ottomans and Safavids).

He defeated and captured Qvarqvare III at the Battle of Murjakheti near Akhalkalaki, Georgians had annexed Principality of Samtskhe.

A few years later, his survived youngest son Kaikhosro II requested Ottomans to expel Imeretian and Kartlian forces from Samtskhe.