Many notable Belarusian cultural figures of the 20th century graduated from the school.
The Belarusian Gymnasium of Vilnius was founded in early 1919, by the allowance of the Council of Lithuania and functioned later during the Interbellum, when the city belonged to Poland.
Prior to their retreat from the city to Kaunas, Lithuanians allowed opening of the gymnasium in the premises of the former Basilian monastery.
In the first year of its existence the school also served as an Orphanage for children from surrounding regions.
It was reestablished after the Collapse of the USSR as the Francishak Skaryna Belarusian School of Vilnius.