The orphanage was established by the Midwest division of B'nai B'rith, an international Jewish social service organization.
B'nai B'rith purchased a building that had been built by Dr Seele as the Cleveland Water Cure Establishment in 1848.
[3] This building originally "was a combination sanitarium and resort for the treatment of various ailments and diseases through hydropathy" "enjoying regional popularity for nearly 2 decades", before being sold in 1868 to the B'nai B'rith organisation, and initially being called the Jewish Orphan Asylum.
Established originally to serve orphaned and destitute Jewish youngsters from 15 midwestern and southern states", and "was located on over seven acres of land near Fifty-fifth Street and Woodland Avenue."
In 1919, as part of the transformation to a more humane place to live, the name was changed to Jewish Orphan Home.