It is 14.34 miles (23.08 km) long and runs east–west, entirely within Yamhill County.

OR 153 begins at an intersection with OR 18 at Bellevue and heads east to Amity.

At Amity, OR 153 overlaps OR 99W for 0.07 miles (0.11 km), heading south.

OR 153 then continues east through Hopewell, ending at an intersection with OR 221 1.34 miles east of Hopewell, near the Maud Williamson State Recreation Site.

By continuing south on OR 221 (Wallace Road) for 0.3 miles to Wheatland Road, it is possible to cross the Willamette River into Marion County via the Wheatland Ferry.