He played college football for the LSU Tigers, earning consensus All-American honors, and winning the Rimington Trophy.
[a] He signed with the Cincinnati Bengals as an undrafted free agent in 2005, and also played for the Atlanta Falcons, and the Florida Tuskers of the United Football League (UFL).
He received an athletic scholarship to attend Louisiana State University, where he played for coach Nick Saban's LSU Tigers football team from 2001 to 2004.
Wilkerson was a PE teacher and assistant football and track coach at North Shore Senior High School in Texas during 2014.
[6][7] Wilkerson coached the team's offensive line when Dave DeGuglielmo missed their week 17 game against the Dallas Cowboys on January 3, 2021.