Bendroflumethiazide is a thiazide diuretic which works by inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT).

Bendroflumethiazide has a role in the treatment of mild heart failure although loop diuretics are better for reducing overload.

It is advised that those using this diuretic should abstain from alcohol consumption during use, as it is possible to experience a sudden drop in blood pressure, especially if standing up (an effect known as orthostatic hypotension).

Pregnant or lactating women with hypertension may need to discuss with their prescriber as to which alternative treatment may be more suitable.

Bendroflumethiazide may also impair the user's motor skills, therefore it is important to be aware of its effects and to take caution when operating machinery of driving.