In 1879 with the completion of the Severn Railway Bridge the Sharpness branch became a through-route to Lydney and the Forest of Dean.

As with the Stonehouse and Nailsworth Railway junction at Stonehouse (Bristol Road) railway station further up the Bristol and Gloucester line towards Gloucester, the actual junction for the Sharpness line was to the north of Berkeley Road station, and branch line trains departed from and arrived at a new set of platforms built at a tangent to the existing Brunel-designed station.

The junction was controlled by a signalbox at the north end of the branch line up (towards Gloucester) platform.

Berkeley Road, like Stonehouse to the north and Mangotsfield to the south, was considered one of the more important stations on the Bristol and Gloucester line and some long-distance trains called there.

Damage to the Severn railway bridge in 1960 led the branch to cease being a through-route and passenger services were withdrawn in November 1964, though it remains open for some goods traffic.