It was built after the Bombing of Frankfurt am Main in World War II along the route of the old Schnurgasse.

This was the second major road breakthrough in the area of the Old Town, after the Braubachstrasse, which was located further south, had already been built between 1904 and 1908.

The street follows the former Schnurgasse in the eastern section, but was built many times wider than the previously existing narrow Altstadtgasse.

The part to the west of the Neue Kräme, on the other hand, was laid out without taking the previous street plan into account.

The last major change to Berliner Strasse took place in 1973 with the opening of the Theater Tunnel, for whose connection a long ramp was built at the western end of the street.