In 1890, the JLB finally went to the newly founded Jura–Simplon Railway (Jura-Simplon-Bahn, JS), which also acquired the Bern–Lucerne line from the canton of Bern.

New double-track sections went into operation between Worb and Tägertschi, Konolfingen and Zäziwil and Bowil and Emmenmatt at the timetable change on 12 December 2004, enabling an hourly Bern–Lucerne service on this line.

Furthermore, a RegioExpress service runs hourly between Lucerne and Bern, consisting of a Lötschberger class (Ra535) set.

Until the timetable change in 2004, two-hourly SBB InterRegio services ran from Lucerne to Bern and onto Geneva Airport, stopping in Wolhusen, Langnau and Konolfingen and, at the edges of the day, also in Schüpfheim.

Since 2004, these trains have been routed via Zofingen and the Mattstetten–Rothrist new line, to enable a travel time of 60 minutes between Bern and Lucerne.