[1] A member of a cadet branch of the Medici family (the one later called the Princes of Ottajano), he was the son of Ottaviano de' Medici (14 July 1482 - 28 May 1546) and second wife as her second husband (1533) Francesca Salviati (1505 - aft.
In 1567, he bought the Seigniory of Ottaiano in the Kingdom of Naples from Cesare I Gonzaga and moved there, probably due to strife with Grand Duke Cosimo I.
His son Alessandro (died 1606) was Lord of Ottaiano and General of the Papal States.
His descendants unsuccessfully claimed the title of Grand Duke of Tuscany after the extinction of the main branch of the Medici family.
[2] Bernardetto married the illegitimate daughter of the Duke Alessandro de 'Medici, Giulia, in 1559.