Bernard Malissen, born on 29 November 1953 in Agen, is a French biology researcher specialising in immunology.
[2] Bernard Malissen is the founder and director of the Centre for Immunophenomics (CIPHE).
[3] Bernard Malissen's work focused mainly on describing the genetic recombination mechanisms that allow the synthesis of T-cell receptors (TCR)[4] - the surface receptor that triggers cell differentiation of the T-cell that carries it and contributes to the body's defences against infectious agents or tumours - and on studying their three-dimensional structure.
[10][11] Using functional genomics tools, Bernard Malissen was able to describe the different types of dendritic cells - which are responsible for capturing and presenting T cell antigens particularly effectively - present in tissues such as skin and how they perform sentinel functions.
[12][13][14] To understand the complexity of signal transduction networks involved in the activation of T cells and dendritic cells, Bernard Malissen is currently using so-called "omics" approaches to simultaneously measure a large number of parameters and describe how T lymphocytes function under normal and pathological conditions.