Distribution of Berthellina quadridens includes Mexico, Belize, Colombia, Costa Rica, Panama, Venezuela, Aruba, Curaçao, Haiti, Jamaica, Puerto Rico, Virgin Islands, Sint Maarten, St. Lucia, Guadeloupe, Martinique, Barbados, St. Vincent and the Grenadines, Grenada, Trinidad and Tobago, Brazil.

[3] Dorsum is smooth, covering the internal shell, which is located over the anterior portion of the viscera.

[3] The anterior end of the body has a large oral veil.

[3] Welch (2010) listed that the maximum recorded length is 80 mm.

[4][clarification needed] Minimum recorded depth is 0 m.[4] Maximum recorded depth is 50 m.[4] It possibly feeds on sponges and likely on the corals Orbicella faveolata and Orbicella annularis as well as on Anemones.