[3] Comstock graduated from The College of William and Mary in 1982 with a Bachelor of Science in biology and a minor in anthropology.

[citation needed] Realizing she "want[ed] to tell stories about science", Comstock interned at a public radio station, afterwards transitioning to local television reporting in Virginia and public-access television in Washington, D.C.[3][4] She moved to NBC as a publicity coordinator in the mid-1980s.

[5] Based on this success, Comstock was recognized by Jack Welch and promoted to higher-level roles inside GE, which owned NBC at the time.

[7] From 2006, she was President of Integrated Media at NBC Universal overseeing ad sales, marketing and research, and led the company's digital efforts including Peacock Equity, acquiring iVillage.com and oversaw the founding of Hulu.

In Sept 2018, Comstock released her first book "Imagine It Forward: Courage, Creativity and the Power of Change".