Passenger service to Philadelphia on the SEPTA Regional Rail Bethlehem Line lasted until 1981.

In 1745, the Crown Inn was established as Bethlehem, Pennsylvania's first public house to serve stagecoach travelers.

[2] Lehigh Valley passenger service ended on February 4, 1961, the last trains being the Maple Leaf and John Wilkes.

[8] Some restoration work was performed on the derelict station in the 1980s, but it was unused until Ashley Development Corporation refurbished it in 2002.

[2][9] St. Luke's Hospital moved clinics into Union Station in 2003, and bought the building outright in 2008.