In 2003, Mould-Iddrisu was appointed the Director of the Legal and Constitutional Affairs Division of the Commonwealth Secretariat, an inter-governmental organisation comprising 53 member states based in London.

Some of the highlights of her time at the Secretariat include overseeing implementation of mandates in the area of transnational crime, counter terrorism and international humanitarian law.

Between 1990 and 2000, at a time she was fulfilling her duties at the London-based Commonwealth Secretariat, she taught at the law faculty of University of Ghana, also publishing various papers and articles on intellectual property.

[23] In July 2023, she interrogated the importance of the Office of Special Prosecutions, suggesting that it was set up by the National Patriotic Party (NPP) government to go after people they disagreed with politically.

[24] Betty Mould-Iddrisu is the wife of former Minister of Defence Mahama Iddrisu and the elder sister of Alex Mould, a former chief executive officer of Ghana National Petroleum Corporation.