Biagio Assereto (c. 1383 – 25 April 1456) was an Italian admiral at the service of the Republic of Genoa.
In 1435 he led a small fleet to Gaeta at the rescue of Francesco Spinola, besieged by Alfonso V of Aragon, and was victorious in the following Battle of Ponza.
Despite his refusal to continue due war, due to the lack of troops to invade the Neapolitan mainland, he received the fief of Serravalle Scrivia and, by the Genoese ally Filippo Maria Visconti, the position of governor of Milan.
He later served Francesco Sforza (1450) but, two years later, he abandoned any public position and retreated at Serravalle to devote to literature.
His friends included Enea Silvio Piccolomini, the future pope Pius II.