She debuted her acting career by featuring in the 2006 Chinese films McDull, the Alumni and The 601st Phone Call.

The extended play was followed by her debut studio album titled Who Touched My Violin String released in August 2006.

In March 2007, she attended the Encore Program at the Musicians Institute in Los Angeles, California, United States to take singing classes.

After she finished her courses at Musicians Institute, Zhou returned to China and prepared for her next studio album.

In April 2008, she featured in the theme song "Beijing Welcomes You" for the 100-day countdown of the 2008 Summer Olympics.

In the same month, she joined the public benefit campaign 56 Ethnic Groups, One Dream as a young ambassador along with Hong Kong singer and professional swimmer Alex Fong.

In October 2012, Zhou signed a recording deal with Yuehua Entertainment, and opened her own studio at the same time.

In March 2015, she won a Nickelodeon Kids' Choice Award for Favorite Chinese Act.