His father, He Wei (Chinese: 何畏; pinyin: Hé Wèi), who was a professor of philosophy, ran a seafood restaurant chain.

His elder brother He Hao (Chinese: 何昊; pinyin: Hé Hào) is a military personnel.

In 2004, He debuted as a singer with the album Keyi Ai (Chinese: 可以爱), featuring Gardenia in Blossom as the main single.

Since 2015, He has hosted the cooking show Go Fridge, a spin-off of Please Take Care of My Refrigerator, with Jackson Wang of Got7.

[6] In 2022, following the unexpected closure of the show Happy Camp, which marked the end of its 24-year run, He began hosting Hello, Saturday as its replacement program.

He Jiong currently holds the Guinness World Record as the most-followed male celebrity on the Chinese social media platform Weibo,[7] with over 115 million followers, as of February 2023.