[1] He has performed OSTs for numerous high-profile Chinese films and TV series, including Big Fish & Begonia, Jiang Ziya, and The Wandering Earth 2, among many others.

He and his older sister were left behind children, as his parents were very poor and would leave to find work in the city, only coming home once a year.

However, after a year, he made the decision to transfer to Lviv National Musical Academy to study Bel canto instead.

[9][10][11] Zhou participated in The Voice of China (season 3) and amazed the coaches with his cover of Chyi Yu's "Huan Yan" in the blind audition round.

On 8 August 2015, Zhou's first single, "The Rose and the Deer", was released, and he won the Best New Artist of ERC Chinese Top Ten Awards.

[19] "Big Fish" and "The Rose and the Deer" were both selected as part of the Top 10 Hits Songs of Fresh Asia Music Award 2016.

[21] Following the phenomenal success of "Big Fish", other films and series began to invite Zhou to perform songs for them, including "Echo" for the series The Starry Night The Starry Sea, "Calm Romance" for the film Brotherhood of Blades II: The Infernal Battlefield, and "Speechless" for the Chinese animation Dahufa.

[29] In November, Zhou participated in the show Super–Vocal, where his performance of classic songs including "Time to Say Goodbye", "Memory", "Think of Me", and "The Lonely Goatherd" received extremely high praise from industry professionals.

[30][31] He participated in The Masked Singer again, this time using his Bel canto skills and versatile vocals to mislead the guessing panel.

[32] In 2019, Zhou performed over 20 songs for various films and TV series, including "With the Wind" for Mystery of Antiques, "Only You" for Relying on Heaven to Slaughter Dragons, "Longing for a Wholehearted Lover" for Royal Nirvana, and "Untouchable" for The Upside.

On the 1 and 2 November 2019, he participated in the Nanjing The Untamed music concert, performing his song "Passing by the Deserted City".

From November 2019 to January 2020, he held his second concert tour, named Planet C-929, with stops in Beijing, Nanjing, Suzhou, Chengdu, Shanghai, and Guangzhou.

[34] From October 2019 to January 2020, Zhou participated in the first season of the singing competition Our Song, broadcast by Dragon TV, where his duets and comedic interactions with his senior partner, cantopop legend Hacken Lee, widely contributed to the popularity of the show.

[38][39] This version has been widely praised by China's domestic music critics, noting how his viral performance has contributed to the spread of ACGN culture.

On 19 July 2020, the establishment of Zhou Shen Studios was officially announced after his six year contract with The Voice of Dreams ended.

[50] Starting from 4 November, Zhou Shen appeared in a workplace-observational reality show An Exciting Offer Season 2.

[70] On 9 April, Zhou participated in the Global Diplomats’ Chinese Cultural Night, where he was awarded the 2020 Most Influential Youth Singer of the Year.

One of the reasons the program director, Yao Yitian, invited him was because of Zhou Shen's thoughtfulness and consideration towards others, contributing to the atmosphere of the show.

[77] On 21 January 2023, Zhou made his second appearance at CCTV's Spring Gala Festival, performing the song "Blossoming Flowers, Forgetting Sorrows" (花开忘忧).

[80] On February 9, 2024, Zhou made his third appearance in CCTV Spring Festival Gala with the song “Health Order” (健康到到令).

[81] On 18 April, Zhou was invited to attend the 15th annual United Nations Chinese Language Day at the UN headquarters in New York.

On February 17, refund and compensation process for the cancelled show was announced: ticket refunds will be automatically processed through the official ticket retailer AXS, domestic travel and international train expenses will be reimbursed in full while lodging and international flight expenses will be reimbursed up to a set amount.