[3] People with BAV may become tired more easily than those with normal valvular function and have difficulty maintaining stamina for cardio-intensive activities due to poor heart performance caused by stress on the aortic wall.

[4][5][citation needed] BAV may become calcified later in life, which may lead to varying degrees of severity of aortic stenosis that will manifest as murmurs.

[8] The extracellular matrix of the aorta in patients with BAV shows marked deviations from that of the normal tricuspid aortic valve, specifically reduced Fibrillin-1.

[12][13][14][16] Identifying hemodynamic patterns in the aorta after left ventricle systole aids in predicting consequential complications of bicuspid aortic valve.

[12][13] The specific zones where blood hits is dependent on the varying BAV leaflet fusion patterns and consequently correlates with increases in WSS.

[12][16] The resulting rise in WSS is supported by the asymmetrical displacement of blood flow produced by an increased angle of outflow from the BAV.

[12] Blood does not flow centrally through the aorta in BAV, but along the right-anterior and right-posterior vessel wall for RL and RN leaflet fusion respectively.

[12][13] Identification of hemodynamics for RL, RN, and left coronary and noncoronary leaflet fusion patterns enables detection of specific aortic regions susceptible to dysfunction and the eventual development of disease.

[12] Hemodynamic measurements from 4D MRI in patients with BAV are advantageous in determining the timing and location of repair surgery to the aorta in aortopathy states.

[citation needed] If the valve is normally functioning or minimally dysfunctional, average lifespan is similar to that of those without the anomaly.

Four-dimensional magnetic resonance imaging (4D MRI) is a technique that defines blood flow characteristics and patterns throughout the vessels, across valves, and in compartments of the heart.

[12][13][19] Four-dimensional imaging enables accurate visualizations of blood flow patterns in a three-dimensional (3D) spatial volume, as well as in a fourth temporal dimension.

[citation needed] Bicuspid aortic valves are the most common cardiac valvular anomaly, occurring in 1–2% of the general population.

Other congenital heart defects are associated with bicuspid aortic valve at various frequencies, including coarctation of the aorta.