The building for the high school was erected on Washington Street close to the city's downtown.

After a rise in Biddeford's population in the late 19th-century, a new high school was constructed in 1888 on a lot in close-by Alfred Street.

[6] The high school moved out of the Alfred Street building in the 1960s to its present location farther away from the Downtown core.

[8] The school has a long-standing football rivalry with Saco's Thornton Academy dating to 1893 which is referred to as the "Battle of the Bridges" by residents of both communities.

[25] Biddeford students taking part in the 1971 Southern Maine Regional Science Fair held at Falmouth High School came home with five of the nine first-place awards.