When the pyloric sphincter is damaged or fails to work correctly, bile can enter the stomach and then be transported into the esophagus as in gastric reflux.
[3] Bile reflux has been associated with gastric cancer, chemical gastritis and the development of ulcers.
The dosage is usually of: Adult(body-weight 47kg and above): 250mg once daily for 10-14 days, dose to be taken at bedtime.
[5] Biliary reflux may also be treated surgically, if medications are ineffective or if precancerous tissue is present in the esophagus.
[6] Obesity is an independent risk factor for development of bile reflux.