Kartalopoulos graduated from Dartmouth College, where he co-founded the student comics anthology Vox Pop Comix.

[3] Features for that publication included an extensive two-part history of RAW Magazine for which Kartalopoulos conducted interviews with Françoise Mouly, Charles Burns, Kim Deitch, Gary Panter, Art Spiegelman, Chris Ware, and others.

"[9] In 2009, he co-founded the Brooklyn Comics and Graphics Festival (BCGF) with Desert Island owner Gabe Fowler and PictureBox publisher Dan Nadel.

[10] For the 2012 edition of the BCGF, Kartalopoulos conducted a conversation with Richard McGuire, Spiegelman, and Ware at the Knitting Factory and organized international programming featuring guests from France, Belgium, Finland, Mexico and Croatia.

[27] He also guest-edited the February–March 2015 comics-themed issue of the American Book Review, featuring contributions from Austin English, John Hankiewicz, Nicole Rudick, Dash Shaw, and others.

[28] Kartalopoulos additionally served as Associate Editor for Multimedia on Art Spiegelman's 2012 book MetaMaus, which included a DVD with video, audio, photos, and an interactive version of Maus.

[29] He also worked as a production and editorial assistant for the first two seasons of Françoise Mouly's TOON Books imprint of comics for early readers.

Kartalopoulos has curated a number of comics-related exhibits in the US and internationally, showing work by artists including Lynda Barry, Alexis Beauclair, Kim Deitch, Aidan Koch, Javier Mariscal, Richard McGuire, Son Ni, Paper Rad, Raymond Pettibon, Deb Sokolow, Saul Steinberg, Chris Ware, and others.

[7] He has contributed essays to books including The Search for Smilin' Ed by Kim Deitch; Vanishing Perspective by Alexis Beauclair; and Society is Nix!