The team began play in 2015 after the Southern League's Huntsville Stars relocated to Biloxi following the 2014 season.

Before the arrival of the Shuckers, the only other professional baseball team from Biloxi, Mississippi, was the Gulfport-Biloxi Sand Crabs, who played in the Class C Cotton States League in 1907.

[7] Twenty-nine years later, following several failed attempts to replace Huntsville's aging ballpark, the Stars were sold to Biloxi Baseball, under the leadership of majority owner Ken Young, in January 2014.

[11] The chosen name, "Biloxi Shuckers", celebrates the city's heritage as a center for the oyster and seafood industries.

[11] Their primary logo utilizes a color palette of gulf blue, sand, coral, and black and features an open oyster with a pair of eyes along with the team name.

[14] These included several games originally planned to be held in Biloxi for which the Shuckers were designated the "home" team in their opponents' ballparks.

[17] Orlando Arcia led the scoring with three runs batted in, while the Shuckers' pitching staff held their opponents to three hits and struck out nine batters.

[16] The team's MGM Park home opener was played on June 6 versus the Mobile BayBears, a 4–3 victory.

[19] The Southern League uses a split-season schedule wherein the division winners from each half qualify for the postseason championship playoffs.

[22] Jorge López won the Southern League Most Outstanding Pitcher Award with a league-leading 1.10 WHIP and a .205 opponents' batting average while tying for the lead with 12 wins.

[24] Brewers appearing in the game included Ryan Braun, Domingo Santana, Jonathan Villar, Martín Maldonado, and Chase Anderson.

[33] Zack Brown won the Most Outstanding Pitcher Award after leading the circuit with a 2.48 earned run average.

[37] Jeffrey Baez of the Jackson Generals won the previous day's Home Run Derby.

[42] Biloxi's 2021 opener in the new league, scheduled for May 4 on the road versus the Birmingham Barons at Regions Field, was postponed due to inclement weather.

[47] In 2022, the Double-A South became known as the Southern League, the name historically used by the regional circuit prior to the 2021 reorganization.

[62] Live audio broadcasts are also available online through the team's website and the MiLB First Pitch and TuneIn radio apps.

[62] All home and road games can be viewed through the MiLB.TV subscription feature of the official website of Minor League Baseball, with audio provided by a radio simulcast.

[65] He made his debut on April 2, 2016, during an exhibition game against the Milwaukee Brewers prior to the Shuckers' first full season at MGM Park.