[2]: 177 In January 1964 given the need for heavier aircraft to be available for quick reaction air support in the Mekong Delta, CINCPAC approved the construction of a new airfield at Cần Thơ for a cost of US$2.5 million to be ready within one year.

[4][5] In June 1965 the base became a forward operating location for AC-47 Spooky gunships of E Flight of the 4th Air Commando Squadron.

[6]: 35 On 15 September 1965 Detachment 10, 38th Aerospace Rescue & Recovery Squadron equipped with 2 HH-43F helicopters deployed to the base to support flight operations.

[5] In February 1970 as part of the process of Vietnamization the USAF began handing over control of Binh Thuy to the RVNAF 4th Air Division and this was completed by the end of the year.

[10] On 19 April 1969 Light Attack Squadron 4 (VAL-4) began combat operations, flying air support for the Mobile Riverine Force in the Mekong Delta.

In the 1975 Spring Offensive, the Army of the Republic of Vietnam 21st Division defended Binh Thuy from the attacking PAVN.