[2][3] It is published by Oxford University Press and, as of 2014, the editors-in-chief are Alfonso Valencia and Janet Kelso.

[4] Previous editors include Chris Sander, Gary Stormo, Christos Ouzounis, Martin Bishop, and Alex Bateman.

[7][8] As of 2005,[update] PLOS Computational Biology became the official ISCB journal.

[7] In January 2009 Bioinformatics again became an official journal of the ISCB, alongside PLOS Computational Biology.

[10][11][12] Following budget problems, Greek universities dropped their subscriptions to Bioinformatics in 2013.