Bioinstructive materials provide instruction to biological cells or tissue, for example immune instruction when monocytes are cultured on certain polymers they polarise to pro- or anti-inflammatory macrophages with potential applications in implanted devices,[1][2] or materials for the repair of musculoskeletal tissues.
[5] Applications of bioinstructive materials as substrates for stem cell production,[6] cell delivery and reduction of foreign body reaction[7][8] and coatings to reduce infections on medical devices.
[9][10] This non-leaching approach is distinct from strategies of infection control relying on antibiotic release,[11] cytokine delivery[12] or guidance of cells by surface located epitopes[13] inspired by nature.
T cells are extracted from the patient and mixed with a genetically engineered virus that contains a cancer targeting gene (as with CAR T).
And because the cells are younger, they last longer in the body, show stronger potency against cancer, and display fewer markers of exhaustion.