Roman Catholic Diocese of Acquapendente

The Italian Roman Catholic diocese of Acquapendente was an ecclesiastical territory in Lazio.

The seat of the bishop was in the cathedral of Acquapendente, dedicated to the Holy Sepulchre (San Sepolcro).

In punishment of this crime, Pope Innocent X ordered Castro to be destroyed, and raised Acquapendente to the dignity of an episcopal city (Bull, 13 September 1649), directly under the Holy See.

The first incumbent of the new See was the Hieronymite Pompeo Mignucci of Offida, who had been Archbishop of Ragusa.

The title of Acquapendente, though not the diocese structure, was revived in 1991, to serve as a titular see.