Geographical barriers, such as the newly forming Rocky Mountains, may have isolated the more southerly Bistahieversor from more derived northern tyrannosaurs.

[9] Bistahieversor differs from other tyrannosaurs in the possession of 64 teeth, an extra opening above the eye, and a keel along the lower jaw, among many other unique traits.

These results are displayed in the cladogram below:[11] Dryptosaurus aquilunguis Appalachiosaurus montgomeriensis Bistahieversor sealeyi Gorgosaurus libratus Albertosaurus sarcophagus Qianzhousaurus sinensis Alioramus remotus Alioramus altai Teratophoneus curriei Dynamoterror dynastes Lythronax argestes Nanuqsaurus hoglundi Thanatotheristes degrootorum Daspletosaurus torosus Daspletosaurus horneri Zhuchengtyrannus magnus Tarbosaurus bataar Tyrannosaurus rex In 2024, Rivera-Sylva & Longrich described new remains likely belonging to a novel species of Labocania.

Their new data allowed for the reanalysis of Bistahieversor as a member of the tyrannosaurine clade Teratophoneini, in addition to Labocania, Dynamoterror, Teratophoneus, and two unnamed specimens from the Aguja and Two Medicine formations.

Its large olfactory bulbs indicate a very heightened sense of smell, while the elongated semi-circular canals implied increased agility and sophisticated gaze stabilization while the head was moving.

The study noted that, while Bistahieversor had small optic lobes, this was not a strong indicator of whether or not this dinosaur possessed poor vision.