It runs between St George's Circus at the southern end and Blackfriars Bridge over the River Thames at the northern end, leading to the City of London.
Halfway up on the west side is Southwark Underground station, on the corner with The Cut.
Opposite is Palestra, a large office building which houses the Surface transport division of Transport for London, which was formerly the headquarters of the London Development Agency.
[1] From 2010 a number of major development schemes have transformed Blackfriars Road from the bridge to the south at St George's Circus and new buildings have replaced the post World War II offices with residential and hotel accommodation along its length, especially at the junction with Stamford Street where major high rises have been erected, such as the 166.3 m (546 ft) tall One Blackfriars.
[2] In April 2024, Southwark Liberal Democrat councillor Victor Chamberlain proposed a rainbow plaque be unveiled on Blackfriars Road to commemorate James Pratt and John Smith, who in 1835 were arrested nearby and became the last men executed for sodomy in England.