As population in the area grew, regionalization was discussed as a way to provide a new high school for Blackstone and Millville.

Blackstone and Millville maintained separate K-6 school committees until 1982, when school budget cuts resulting from Massachusetts Proposition 2½ going into effect pushed the towns to work out a plan to modify the regional district to establish a K-12 regional district, approved by voters at Special Town Meetings in April 1982.

[1] The Blackstone-Millville Regional Chargers compete in the Dual Valley Conference.

The boys' cross-country team won 265 consecutive dual meets between 1974 and 1993,[6] a national record that stood until 2004.

[7] The Blackstone-Millville Regional High School Chargers Marching Band has traveled throughout North America for national competitions and parades, including the National Cherry Blossom Festival,[8] the Rose Parade,[9] and the Macy's Thanksgiving Day Parade.