[13] Before deciding to focus on basketball, Griffin also played baseball as a first baseman and football as a wide receiver, safety, and tight end.

[15] In Griffin's sophomore year, the Saints repeated as Class 3A state champions, defeating Sequoyah-Tahlequah 51–34, where he scored 12 points and grabbed nine rebounds.

He scored 22 points, grabbed nine rebounds, and recorded six blocks in the finals as Oklahoma Christian defeated Washington High School, 57–40.

[6] Capel liked the fact that Griffin had not yet become a household name among recruiters and felt he was exactly the player whom he needed to rebuild the Oklahoma men's basketball program with.

[6] Griffin had been considering Duke, Kansas, North Carolina, and Texas,[6] but his brother eventually sold him on joining Oklahoma when he raved about the direction of the Sooners and the chance to play together again for his home state.

[27] The Saints advanced through the playoffs, defeating Crescent in the quarterfinals and Foyil in the semifinals to earn a berth in the Class 2A state championship once again.

[18] Griffin registered 22 points, nine rebounds, six assists and two blocks, as the Saints defeated Pawnee 81–50, winning their fourth straight state title.

[37] He missed the following game, a victory over in-state rival Oklahoma State Cowboys,[38] but was back on the court a week after the injury with 14 points and eight rebounds in a win versus Missouri.

[39] He was expected to be a lottery pick in the 2008 NBA draft but decided to return to college to give himself time to mature physically and try to help Oklahoma win the NCAA championship.

[46] After sitting out the next game, a loss to Kansas Jayhawks, he was cleared by the medical staff and returned a week later to get 20 points and 19 rebounds in a victory over Texas Tech.

He was a unanimous choice by voters in all nine geographical districts for the Oscar Robertson Trophy and was named Associated Press College Basketball Player of the Year, receiving 66 of the 71 national media panel members' votes.

[64] The day before the 2009–10 season started, it was confirmed that Griffin had a stress fracture in his left knee, delaying his NBA debut for seven weeks.

On March 6, 2013, Griffin recorded his third career triple-double by scoring 23 points, grabbing 11 rebounds, and dishing out 11 assists to lead the Los Angeles Clippers to victory over the Milwaukee Bucks.

After a disappointing first round exit in the playoffs, the Los Angeles Clippers sought new leadership and hired head coach Doc Rivers.

On April 2, 2014, Griffin and Chris Paul led the Los Angeles Clippers to a 112–108 win over the Phoenix Suns to clinch their second franchise division title.

Former Microsoft CEO Steve Ballmer later bought the Clippers for $2 billion, the largest amount paid for a franchise in NBA history.

[87] On December 8, 2014, Griffin scored a season-high 45 points on 14-of-24 shooting, including a game-winning three-pointer as time expired, as the Clippers beat the Phoenix Suns in overtime 121–120.

On April 22, Griffin recorded his first career playoff triple-double with 29 points, 12 rebounds and 11 assists in a first-round Game 2 series loss to the San Antonio Spurs.

On November 25, 2015, Griffin recorded season-highs with 40 points and 12 rebounds in a loss to the Utah Jazz, with the Clippers dropping to 7–8 after starting the season 4–0.

[99] Griffin missed 45 games in total due to injury and suspension, returning to action for the Clippers on April 3 against the Washington Wizards.

He played 24 minutes as a starter and recorded six points and five rebounds to help the Clippers clinch home-court advantage in the playoffs with a 114–109 win.

[101][102] On November 5, 2016, Griffin scored a season-high 28 points in a 116–92 win over the San Antonio Spurs, helping the Clippers start the season 5–1.

[105] The following day, in a win over the Minnesota Timberwolves, Griffin joined an exclusive club with 9,000 career points, 4,000 rebounds and 1,500 assists.

He became the second player in franchise history to reach that mark, joining Randy Smith, who scored 10,467 of his club-record 12,735 points when the team was known as the Buffalo Braves.

[114][115] On November 22, 2017, he had 26 points, 10 rebounds and 10 assists in a 116–103 win over the Atlanta Hawks, helping the Clippers snap a nine-game losing streak.

[1] He was an exceptional athlete that was known for highlight dunks from alley-oops, similarly to his former teammate DeAndre Jordan, which were integral to the Clippers during the era dubbed "Lob City".

[155][156][157] Rob Mahoney, in a January 2011 post in The New York Times basketball blog, singled out Griffin's playmaking abilities stating, "The overtly dominant aspects of Griffin's play have made him one of the season's greatest delights, but his game clearly stretches beyond the scoring and rebounding columns...his passing aptitude should serve as a reminder of the substance in his game.

[189] The Kia sedan that Griffin jumped over to win the Slam Dunk Contest was donated for a charity auction on AutoTrader.com with proceeds benefiting Stand Up to Cancer.

[190] Stand Up to Cancer also has a fund-raising site called "Team Blake" in honor of Griffin's close friend Wilson Holloway, who died after a three-year fight with Hodgkin's lymphoma.

On March 13, 2020, Griffin pledged to give $100,000 to the staff of the Little Caesars Arena who were unable to work during the suspension of the 2019–20 NBA season because of the 2020 coronavirus pandemic.